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Use of vinyl magnesium bromide in the synthesis of …

Vinyl bromide is used to manufacture bromopolymers and mainlypolyvinyl bromide. Further it is used as an agent.

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condensation of allyl bromide 2 ..

AB - (Chemical Presented). A convenient, one-pot, three-component regioselective synthesis of novel 2,2′-(1,4-phenylene)-bis-(3-aryl-2-substituted imino-4-aryl-3H-thiazole) derivatives from 1,4-phenylene diisothiocyanate, aryl amines, and various phenacyl bromide, and also the regioselective synthesis of 3-alkyl-2-(aryl imino)-4-cyclopropyl-5-(2′-fluorophenyl)-thiazole derivatives from alkylisothiocyanate, aryl amines, and 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone in the presence of poly-4-vinyl pyridine as heterogenous basic catalyst are described. This efficient method produced the products at room temperature with excellent yields (82-96%). The structures of all products were characterized by spectral and elemental analyses. The antimicrobial activity of the synthesized compounds was evaluated against Salmonella enterica, Micrococcus luteus, Bacillus subtilis, and Pseudomonas aeruginosa.

Report on Carcinogens Background Document for Vinyl Bromide; Synthesis of vinyl bromides;
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An initial attempt utilising a Grignard addition of vinyl magnesium bromide under Felkin-Anh control to provide the desired anti-anti stereochemistry proved lengthy and the selectivity could not be improved from a 3.9:1 ratio of anti:syn diastereomers.

Vinyl bromide's wiki: Vinyl bromide is a simple vinyl halide

Vinyl bromide is a simple vinyl halide
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A recent formal synthesis of the complex terpenoid natural product solanoeclepin A has been reported by Hiemstra and co-workers (Scheme []).[] A key step in this synthesis was the vinylation of the bridgehead tertiary boronic ester in . Formation of the trivinyl boronate complex with excess vinylmagnesium bromide in THF followed by addition of iodine and sodium methoxide produced alkene , which was employed without purification in a subsequent sequence of oxidative cleavage and Horner–Wadsworth–Emmons olefination to form in a yield of 67 % over four steps.

In summary, there are currently three methods available to introduce an unsubstituted vinyl group by Zweifel olefination (Scheme []). For aromatic, primary and unhindered secondary boronic esters, the desired boronate complex can be formed efficiently using 1.2 equivalents of vinylmagnesium halide in 1:1 THF/DMSO. For the majority of tertiary boronic esters it is recommended to employ four equivalents of vinylmagnesium halide in THF (to form the trivinyl boronate complex), although with extremely hindered tertiary boronic esters, the best results are obtained with vinyl lithium.

vinyl alkane --> allylic bromide..

Synthesis of Vinyl Bromides Via Reaction of Vinyl …
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Functionalized vinyl pinacol boronates suitable for Suzuki cross-coupling reactions are synthesized using ruthenium-catalyzed olefin cross-metathesis of 1-propenyl pinacol boronate and various alkenes, including functionalized and 1,1-disubstituted alkenes. The resultant boronate cross products are stereoselectively transformed into predominantly -vinyl bromides and -vinyl iodides. The vinyl bromides may be synthesized in a two-step, one-pot synthesis from a variety of olefins, resulting in a -selective formal vinyl bromide cross-metathesis reaction.

N2 - (Chemical Presented). A convenient, one-pot, three-component regioselective synthesis of novel 2,2′-(1,4-phenylene)-bis-(3-aryl-2-substituted imino-4-aryl-3H-thiazole) derivatives from 1,4-phenylene diisothiocyanate, aryl amines, and various phenacyl bromide, and also the regioselective synthesis of 3-alkyl-2-(aryl imino)-4-cyclopropyl-5-(2′-fluorophenyl)-thiazole derivatives from alkylisothiocyanate, aryl amines, and 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone in the presence of poly-4-vinyl pyridine as heterogenous basic catalyst are described. This efficient method produced the products at room temperature with excellent yields (82-96%). The structures of all products were characterized by spectral and elemental analyses. The antimicrobial activity of the synthesized compounds was evaluated against Salmonella enterica, Micrococcus luteus, Bacillus subtilis, and Pseudomonas aeruginosa.

Vinyl halide | Wiki | Everipedia
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  • Vinyl bromide 98% | Sigma-Aldrich

    Allyl bromide

  • Search results for vinyl bromide at Sigma-Aldrich

    VINYL BROMIDE - chemical information, properties, structures, articles, patents and more chemical data.

  • Vinyl iodide functional group - Wikipedia

    Methyl N-Boc-pyroglutamate is cleaved with vinylmagnesium bromide to produce an acyclic γ-vinyl ketone

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Vinyl chloride synthesis by chlorination or substitution

(Chemical Presented). A convenient, one-pot, three-component regioselective synthesis of novel 2,2′-(1,4-phenylene)-bis-(3-aryl-2-substituted imino-4-aryl-3H-thiazole) derivatives from 1,4-phenylene diisothiocyanate, aryl amines, and various phenacyl bromide, and also the regioselective synthesis of 3-alkyl-2-(aryl imino)-4-cyclopropyl-5-(2′-fluorophenyl)-thiazole derivatives from alkylisothiocyanate, aryl amines, and 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone in the presence of poly-4-vinyl pyridine as heterogenous basic catalyst are described. This efficient method produced the products at room temperature with excellent yields (82-96%). The structures of all products were characterized by spectral and elemental analyses. The antimicrobial activity of the synthesized compounds was evaluated against Salmonella enterica, Micrococcus luteus, Bacillus subtilis, and Pseudomonas aeruginosa.

Vinyl bromide. - National Center for Biotechnology …

and and and and and (2012)Naturally occurring himachalenes to benzocycloheptene aminovinyl bromide derivatives: as antidepressant molecules. Molecular Diversity, 16. pp. 357-366.

Carcinogens; Flame Retardants; …

Morken and Blaisdell have reported an elegant stereoselective synthesis of debromohamigeran E that employs a Zweifel coupling of an α-substituted vinyl lithium (Scheme []).[] Cyclopentyl boronic ester was prepared from 1,2-bis(boronic ester) in 42% yield by a highly selective hydroxy-directed Suzuki–Miyaura coupling. This intermediate was then subjected to Zweifel coupling with isopropenyllithium (synthesized by Li–Br exchange) to form in 93 % yield. Completion of the synthesis of debromohamigeran E required four further steps including hydrogenation of the alkene to an isopropyl group.

Base-mediated reaction of vinyl bromides with aryl …

Methyl bromide did not permeate through certain plastics (Herzel & Schmidt, 1984) or through metal or polyvinyl-chloride (PVC) pipes, but permeation through low-density polyethylene (LDPE) occurred.

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