An Efficient Synthesis of Racemic Tolterodine | Korea …
An Efficient Synthesis of Racemic Tolterodine - Tolterodine ; Racemate
API SYNTHESIS INTERNATIONAL: TOLTERODINE
Manufacturing aspects of R-Tolerodine L-tartrate are presented. Initially, five routes are selected for the synthesis of the product but later based on the criteria related to number of steps, cost of reagents, total time required, environmental conditions, purification methods and yield it is found that two of the routes are the most suitable to obtain Tolterodine. Hence, a re-evaluation is made over these two routes in terms of process complexity as an additional criterion which helps select one route as the most feasible one in terms of scale-up in manufacturing process development for R-Tolterodine Ltartrate. The report also explores on the unit operations required to develop the process in which the choice of equipments are made on the basis of cost, efficiency and possible hazards. The entire unit operations and equipments are presented in a form of process flow diagram clearly indicating the reagents, equipments, product, by-products, wastes and the way they are handled in context to the safety issues related to them. The process chemistry is analysed with detailed manifestations on the reaction types, kinetics and thermodynamics giving emphasis on risk assessment and challenges on scaling up the processes. Finally, a thorough discussion is made highlighting the matters regarding the formulation of R-Tolterodine L-tartrate into tablets and capsules.
The configuration of the crucial stereocenter was preserved during the synthesis and the obtained product was identified by chiral HPLC to be the (R)âtolterodine enantiomer.
SHORT SYNTHESIS OF TOLTERODINE, INTERMEDIATES …
The configuration of the crucial stereocenter was preserved during the synthesis and the obtained product was identified by chiral HPLC to be the (R)âtolterodine enantiomer.">
Most common amine protection methods
Rhodium-Catalyzed Asymmetric 1,4-Addition and Its …
He graduated from Kyoto University in 1970
Download Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine download document.
Toronto Research Chemicals - TRC Canada
| Custom Synthesis, Isotope Labeled Internal Standards, Online Catalog: BDG Synthesis
Clarithromycin 500 mg Film-coated Tablets - - (eMC)
Tosyl - Wikipedia
"I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."
"Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."
"Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."
"Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."
"Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."
"Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."