Tetracycline antibiotics - Wikipedia
Synthesis, characterization, and liposome partition of a novel tetracycline derivative using the ionic liquids framework
Medication Guide: Tetracycline Hydrochloride
Minocycline is also synthetic whereas Tetracycline Hydrochloride and Oxytetracyline are naturally occurring. It should also be noted that Minocycline maintains serum levels 2-4 times that of most other tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of Tetracycline Hydrochloride at 24-48 hours).
Oxytetracycline is a naturally occurring Tetracycline that is more broad spectrum than Tetracycline Hydrochloride (but not as broad spectrum as Minocycline, especially as to gram negative bacteria).
Antibiotic Drugs, Information, Description on Tetracycline.
Tetracycline Hydrochloride mode of action is as a protein synthesis inhibitor via an aminoacyl-tRNA binding mechanism to the 30S subunit. Mode of resistance is the loss of cell wall permeability.
Note, Tetracycline can lower red blood cell count and cause anemia, because of this I would not use with injured fish, as this is the last thing you want to do with a bleeding fish.
Tetracycline Hydrochloride is a naturally occurring Tetracycline used in the treatment of bacterial infections that are generally gram-positive such as Streptococcus and SOME gram-negative infections in fish.
It interferes with the production of proteins that the bacteria need to multiply and divide (bacteriostatic). However many bacterial pathogens have developed resistance to Tetracycline Hydrochloride.
Precautions, contraindications and warnings
Doxycycline is a wide spectrum antibacterial synthetically derived from oxytetracycline that is generally superior in our aquatic environments.
Doxycycline also has been shown to have delayed anti-malarial activity, which is a similar pathogen to Oodinium & Ich found in our aquarium pond fish. However this is not a "best product" for this use in our aquarium fish
Results of genotoxicity studies on tetracycline (cont'd) Test system Test object Concentration Result Reference Gene mutation FM3A cells from 10-100 µg/ml positive4 Tsutsui, et al., C3H mice 1976 In vivo Chromosome Allium cepa 12-20 µg/ml5 positive Mann, 1978 aberration assay SLRL assay Drosophila injection: NTP, 1989 melanogaster 5000-5300 ppm negative feeding: 9005 ppm negative 1 with and without metabolic activation 2 S9 prepared from the liver of Aroclor 1254-induced F344 rats 3 S9 prepared from liver of non-induced F344 rats 4 induction of an 8-azaguanine-resistant mutation chromosomal damage inhibition of protein and DNA synthesis 5 TC pure was used as test substance Therapy with TCs is associated with a high rate of development of supra-infections with bacteria, yeast or fungi not sensitive to these agents, particularly in patients with diabetes and other conditions that reduce the natural host defense mechanisms (Pratt & Fekety, 1986).
Tetracycline should never be used after expiry date
Tetracycline Tablets BP 250 mg - - (eMC)
Tetracycline binds with the 70S ribosomes found in mitochondria and can also inhibit protein synthesis in mitochondria
Tetracycline Tablets BP 250 mg - by Intrapharm Laboratories Limited
tetracycline | Sigma-Aldrich
Bionexus DNA marker,Protein Marker,Gene-Peptide Synthesis
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