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Tetracycline antibiotics - Wikipedia

Synthesis, characterization, and liposome partition of a novel tetracycline derivative using the ionic liquids framework

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Medication Guide: Tetracycline Hydrochloride

Minocycline is also synthetic whereas Tetracycline Hydrochloride and Oxytetracyline are naturally occurring. It should also be noted that Minocycline maintains serum levels 2-4 times that of most other tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of Tetracycline Hydrochloride at 24-48 hours).

Chemistries for the synthesis of novel tetracyclines have been previously described

Oxytetracycline is a naturally occurring Tetracycline that is more broad spectrum than Tetracycline Hydrochloride (but not as broad spectrum as Minocycline, especially as to gram negative bacteria).

Antibiotic Drugs, Information, Description on Tetracycline.

28/10/2009 · It was not until 2005 that the Myers group at Harvard reported an efficient total synthesis of tetracycline ..

Tetracycline Hydrochloride mode of action is as a protein synthesis inhibitor via an aminoacyl-tRNA binding mechanism to the 30S subunit. Mode of resistance is the loss of cell wall permeability.
Note, Tetracycline can lower red blood cell count and cause anemia, because of this I would not use with injured fish, as this is the last thing you want to do with a bleeding fish.

Tetracycline Hydrochloride is a naturally occurring Tetracycline used in the treatment of bacterial infections that are generally gram-positive such as Streptococcus and SOME gram-negative infections in fish.
It interferes with the production of proteins that the bacteria need to multiply and divide (bacteriostatic). However many bacterial pathogens have developed resistance to Tetracycline Hydrochloride.

Precautions, contraindications and warnings

Doxycycline is a wide spectrum antibacterial synthetically derived from oxytetracycline that is generally superior in our aquatic environments.
Doxycycline also has been shown to have delayed anti-malarial activity, which is a similar pathogen to Oodinium & Ich found in our aquarium pond fish. However this is not a "best product" for this use in our aquarium fish

Results of genotoxicity studies on tetracycline (cont'd) Test system Test object Concentration Result Reference Gene mutation FM3A cells from 10-100 µg/ml positive4 Tsutsui, et al., C3H mice 1976 In vivo Chromosome Allium cepa 12-20 µg/ml5 positive Mann, 1978 aberration assay SLRL assay Drosophila injection: NTP, 1989 melanogaster 5000-5300 ppm negative feeding: 9005 ppm negative 1 with and without metabolic activation 2 S9 prepared from the liver of Aroclor 1254-induced F344 rats 3 S9 prepared from liver of non-induced F344 rats 4 induction of an 8-azaguanine-resistant mutation chromosomal damage inhibition of protein and DNA synthesis 5 TC pure was used as test substance Therapy with TCs is associated with a high rate of development of supra-infections with bacteria, yeast or fungi not sensitive to these agents, particularly in patients with diabetes and other conditions that reduce the natural host defense mechanisms (Pratt & Fekety, 1986).

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  • Tetracycline Tablets BP 250 mg - - (eMC)

    Tetracycline binds with the 70S ribosomes found in mitochondria and can also inhibit protein synthesis in mitochondria

  • Tetracycline Tablets BP 250 mg - by Intrapharm Laboratories Limited

    tetracycline | Sigma-Aldrich

  • Bionexus DNA marker,Protein Marker,Gene-Peptide Synthesis

    Compare tetracyclines

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