Call us toll-free

Click Synthesis of Fluorine-Rich Cyclotriphosphazene Hydrazones.

Living Radical Polymerization as a Tool for the Synthesis of Polymer-Protein/Peptide Bioconjugates.

Approximate price


275 Words


H., His6 tag-assisted chemical protein synthesis.

A simple and practical approach has been developed for the synthesis of homoallylic amines which avoids the production of toxic stannanes. In this process, the hydrazone, which was formed by reacting benzaldehyde derivatives with 2-aminoisoindoline-1,3-dione, allylic bromide and tin metal under Lewis acid catalytic conditions, provides the target compounds in yields ranging from 53%-92%.

M., Synthesis of bio-inspired hybrid polymers using peptide synthesis and protein engineering.
Photo provided by Flickr

Rajender S. Varma was born in India (Ph.D., Delhi University, 1976). After postdoctoral research at Robert Robinson Laboratories, Liverpool, U.K., he was a faculty member of the Baylor College of Medicine and Sam Houston State University prior to joining the Sustainable Technology Division at the U.S. Environmental Protection Agency in 1999. He has over 40 years of research experience in management of multidisciplinary technical programs and is extensively involved in sustainable aspects of chemistry, which include development of environmentally benign synthetic methods using alternate energy input using microwaves, ultrasound, and mechanochemistry, etc., efficient technologies for greener remediation of contaminants, and environmental sciences. Lately, he has been focused on greener approaches to assembly of nanomaterials and sustainable applications of magnetically retrievable nanocatalysts in benign media. He is a member of the editorial advisory board of several international journals and has published over 430 scientific papers and been awarded 14 U.S. patents.

Solvent-free synthesis of hydrazones and their …

W., Protein semi-synthesis: New proteins for functional and structural studies.
Photo provided by Flickr

Paul Dochety's blog at was a massive inspiration to me in my early days as a blogger, showing me that there was enough of a synthetic organic chemistry community online to make writing seemingly very esoteric posts on a small, specialised sub-field rewarding and worthwhile. A couple of years ago, Paul moved away from the online community, but continued his excellent monthly column for the RSC's (think British C&EN, if you're not familiar with it). However, his tenure there has recently also , and to try to fill the organic-shaped hole in its opinion pages the RSC has commisioned a new column – Organic Matter. As you've probably , authorship will be shared between myself, Karl Collins (of ) and the legendary Chemjobber (anyone who needs a should really rethink their blog-reading priorities).

I'd initially planned to write about the most recent 2 (or possibly all 3) syntheses in an epic all-in-one comparison blog-post, but in the interests of keeping these musings short and somewhat readable I've decided to break things down a bit. This week's installment will cover Sorenson's awesome synthesis from back in April.

Chemical Synthesis and Properties of Hydrazones

J., Synthesis and Evaluation of Coumermycin A1 Analogues that Inhibit the Hsp90 Protein Folding Machinery.
Photo provided by Flickr

I thought I'd quickly share with you a couple of useful transformations involving hydrazones that I read about recently. The first one I found yesterday, reading George Majetich's perovskone in Gilbert Stork's special issue of Tetrahedron. Although it's not the most atom economic thing ever, it struck me as quite a neat, if somewhat oldschool, way to transfer chirality. The second reaction is from Rawal's recent total synthesis of the weltwitindolinones, which I blogged about in detail, and which I actually saw Rawal himself talk about on Tuesday at Bristol. The reason I've brought it up again is that when I wrote my last post commenter MadForIt asked about the mechanism of this transformation, which at the time I didn't know and didn't get round to looking up. By chance I found out the mechanism a few weeks later (completely by accident) but never got round to posting it up. Rawal's talk reminded me of this, but it didn't seem worth burying the answer in the archives so I thought I'd make a new post out of it here.

When the group first published a racemic version of this synthesis back in 2004 they used this modified Wolff-Kishner reaction where the intermediate hydrazone was reduced by the cyanoborohydride. Following loss of tolylsulfinic acid, the reaction proceeds via the intermediate diazene shown below that undergoes a 1,5-rearrangement to lose nitrogen.

E., Synthesis and manipulation of orthogonally protected dendrimers: Building blocks for library synthesis.
Photo provided by Flickr
Order now
  • Synthesis and Study of New N-Substituted Hydrazones …

    Syntheses of Hemoprotein Models that can be Covalently Attached onto Electrode Surfaces by Click Chemistry.

  • Synthesis and Properties of Glass-Forming Hydrazones …

    H., Click chemistry as a route to cyclic tetrapeptide analogs: Synthesis of cyclo-[Pro-Val-y(triazole)-Pro-Tyr].

  • Synthesis and properties of hydrazones of the phenanthridine series.

    S.; Wong, C.-H., 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.

Order now

Synthesis of Aldehyde Hydrazones Containing Pyridazinone

In the four months I spent not writing this post, the Paterson–Dalby synthesis of jiadifenolide was , but as I’d already put a few hours into it I decided to use the Christmas holidays to dust it off and finish it up. Enjoy! —BRSM

The first step should always be the synthesis of the hydrazones.

The applications of copper (Cu) and Cu-based nanoparticles, which are based on the earth-abundant and inexpensive copper metal, have generated a great deal of interest in recent years, especially in the field of catalysis. The possible modification of the chemical and physical properties of these nanoparticles using different synthetic strategies and conditions and/or via postsynthetic chemical treatments has been largely responsible for the rapid growth of interest in these nanomaterials and their applications in catalysis. In addition, the design and development of novel support and/or multimetallic systems (e.g., alloys, etc.) has also made significant contributions to the field. In this comprehensive review, we report different synthetic approaches to Cu and Cu-based nanoparticles (metallic copper, copper oxides, and hybrid copper nanostructures) and copper nanoparticles immobilized into or supported on various support materials (SiO2, magnetic support materials, etc.), along with their applications in catalysis. The synthesis part discusses numerous preparative protocols for Cu and Cu-based nanoparticles, whereas the application sections describe their utility as catalysts, including electrocatalysis, photocatalysis, and gas-phase catalysis. We believe this critical appraisal will provide necessary background information to further advance the applications of Cu-based nanostructured materials in catalysis.

Synthesis of Hydrazones as Antibiotics Ryan P

Great post! I am a big fan of hydrazone chemistry, and it is nice to see it come back once in a while. There is one small mistake near the end of your article: the scheme in the first bonus information features an arrow that eliminates Ar instead of going towards the oxygen during the sulfinate elimination.

Synthesis of aryl hydrazones | …

Given the massive number of people affected worldwide by neurodegenerative diseases and nerve injuries, it's not surprising that a number of synthetic groups have chosen to focus their research programs on neurotrophic[1] natural products. Of course, it's probably coincidence that aside from their potential uses to society, a number of these compounds seem to also be structurally unique and strikingly intricate molecules.[2] One such example is jiadifenolide, whose dense, caged seco-prezizaane-type structure has already seen 3 total syntheses since its isolation five years ago.

Order now
  • Kim

    "I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."

  • Paul

    "Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."

  • Ellen

    "Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."

  • Joyce

    "Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."

  • Albert

    "Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."

  • Mary

    "Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."

Ready to tackle your homework?

Place an order