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Process and Intermediates for the Synthesis of Caspofungin

T1 - The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformans

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Antifungal action: Caspofungin inhibits synthesis of b ..

Caspofungin, an echinocandin, inhibits the synthesis of beta (1,3)-D-glucan, an essential component of the cell wall of susceptible species and species. Beta (1,3)-D-glucan is not present in mammalian cells. Caspofungin has shown activity against species and in regions of active cell growth of the hyphae of .

Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta ..

A novel three-step synthesis of the highly functionalized antifungal agent CANCIDAS (caspofungin acetate, 2) is described, starting from the natural product pneumocandin B0 (1). The highlights of the synthesis include a stereoselective formation of a phenylthioaminal, a remarkable chemoselective, high-yielding, one-step borane reduction of a primary amide, and a stereoselective substitution of the phenylthioaminal with ethylenediamine producing 2 in a 45% overall yield.

cell wall synthesis in caspofungin ..

A total synthetic approach was developed to synthesize structurally diverse caspofungin-like antifungal cyclic lipopeptides, allowing for systemically investigating their SARs.

and and and (2013)Exposure of Aspergillus fumigatus to caspofungin results inthe release, and de novo biosynthesis, of gliotoxin. Medical Mycology, 51. pp. 121-127. ISSN 1232-986X

Caspofungin acetate inhibits the synthesis of ..

EFFECT: obtaining a novel intermediate compound for synthesis of caspofungin, which simplifies method of producing caspofungin and increases its output.

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  • Cancidas - FDA prescribing information, side effects and …

    SUBSTANCE: invention relates to an intermediate compound of formula (I) for synthesis of caspofungin

  • Chapter 20:Antimicrobial Drugs Flashcards | Quizlet

    Mechanism(s) of Action Caspofungin blocks the synthesis of a major fungal cell wall component, 1-3-beta-D-glucan.

  • Treatment of candidemia and invasive candidiasis in …

    Caspofungin blocks the synthesis of a major fungal cell wall component, 1-3-beta-D-glucan

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