A Student Researched Lab Experiment about the synthesis of Aspirin.
Aspirin - Wikipedia
Professor K - sample organic chemistry lab report
It inhibits fatty acid cyclo-oxygenase by acetylation of the active site of enzyme and the pharmacological effects of aspirin are due to the inhibition of the formation of cyclo-oxygenase products including prostglandins, thromboxanes and prostacyclin.Aspirin is prepared by chemical synthesis from salicylic acid, by acetylation with acetic anhydride.
Six years later, in 1859, von Gilm obtained analytically pure acetylsalicylic acid (which he called "acetylierte Salicylsäure", acetylated salicylic acid) by a reaction of salicylic acid and acetyl chloride. In 1869 Schröder, Prinzhorn and Kraut repeated both Gerhardt's (from sodium salicylate) and von Gilm's (from salicylic acid) syntheses and concluded that both reactions gave the same compound—acetylsalicylic acid. They were first to assign to it the correct structure with the acetyl group connected to the phenolic oxygen.
a fungistatic compound that is widely used as a food preservative
Aspirin has been shown to have at least three additional modes of action. It uncouples in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons. In short, aspirin buffers and transports the protons. When high doses of aspirin are given, aspirin may actually cause fever owing to the heat released from the electron transport chain, as opposed to the antipyretic action of aspirin seen with lower doses. Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduced leukocyte adhesion, which is an important step in immune response to infection; however, there is currently insufficient evidence to show that aspirin helps to fight infection. More recent data also suggests that salicylic acid and its derivatives modulate signaling through . NF-κB is a complex that plays a central role in many biological processes, including inflammation.
The Coxibs, Selective Inhibitors of Cyclooxygenase-2 ? …
09/08/2001 · Review Article
The Coxibs, Selective Inhibitors of Cyclooxygenase-2
Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation
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Aspirin acetylsalicylic acid Chemistry Tutorial - AUS-e …
Mechanism of action
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