Synthesis and antifungal activity of some chalcone ..
Hamada," Synthesis and in vitro antimicrobial activity of some pyrazolyl-1-carboxamide derivatives.
Synthesis and antimicrobial activity of some ..
Antimicrobial Activity: Nagaini et al., successfully synthesized anew homologues series of chalcone derivatives as antimicrobial agents and the anti- bacterial activity against E. coli where the presence of hydroxyl group at the ortho position(1) showed better antimicrobial activities as compared to para position(2) 4.
A series of novel chalcone linked imidazolones were synthesized and evaluated byKamal et al., for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these (51a, 51b and 51c) showed good anti-cancer activity with GI50 values ranging from 1.26 to 13.9 μM35.
antimicrobial activity of some new chalcones ..
Carla et al., showed a new set of sulfonamide 4-methoxychalcone derivatives (25a–25i) were synthesized and which shown antileishmanial activity against Leishmania braziliensis promastigotes and intracellular amastigotes and determined its cell toxicity profile. Interestingly all compounds presented a concentration-dependent antileishmanial profile and the benzylamino derivative (25i) showed a biological activity better than pentamidine 19.
Antileishmanial Activity: Paula et al.,were studied the eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and some derivatives, and these analogues were tested for selective activity against both promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro. Three analogues (23a, 23b, and 23c) containing nitro, fluorine or bromine groups, respectively, displayed increased selective activity against the parasites as compared with the natural chalcone.
Synthesis and Antimicrobial Activity of Some New 3 …
Some new azo-flavones of 2-(substituted phenyl)-6-(p-tolyldiazenyl)-4H-chromen-4-ones, have been synthesized in three consecutive main steps. 4-toluidine was used as a diazotizing agent and subjected to coupling reaction with 2-hydroxyacetophenone forming 2-(hydroxyl)-5-[4-methylphenylazo] acetophenone as a key substrate. The prepared starting material reacted with different substituted benzaldehydes affording new 2-hydroxy azo-chalcones which were cyclized by DMSO/I2 giving the target biological active azo-flavone derivatives. The structures of the newly synthesized products were elucidated by using FT-IR, 1H-NMR, 13C-NMR and DEPT-135 spectra. The synthesized flavones were screened with two types of bacteria Escherichia coli gram negative and Staphylococcus aurous gram positive. The results observed a significant effect against gram negative bacteria.
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim of this review is to summarize chalcones and their diverse pharmacological activities like anticancer, antimicrobial, analgesic and antiviral activities etc.
Synthesis and Antimicrobial Activity of Some ..
synthesis and antimicrobial activity of some new 1,3,5 ..
Synthesis and Molecular modeling of some new chalcones derived from coumarine as CDC25 phosphatases inhibitors
» Future Issue | Pakistan Journal of Pharmaceutical …
synthesis, antimicrobial activity and molecular docking study of some new n-benzyl and n-benzoyl-3-indolyl heterocycles
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Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry
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Tavares et al., reported a series of new 6-quinolinyl and quinolinyl N-oxide chalcones were efficiently preparedby synthesized all chalcones were tested by minimal inhibitory concentration (MIC) against three species of Candida, Cryptococcus gattii and Paracoccidioides brasiliensis. The effect of these compounds was also tested on the survival and growth of the human cancer cell lines UACC-62 (melanoma), MCF-7 (breast), TK-10 (renal) and leukemic cells, Jurkat and HL60. The cytotoxic activity showed that compounds 40c and 41e, presented the best activity against MCF-7 and TK-10 21.
Bioorganic & Medicinal Chemistry Letters | Vol 20, Iss …
Liaras et al., synthesized a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties and antifungal properties and evaluation of antibacterial activity showed that almost all the compounds 9a-j exhibited greater activity than reference drugs and thus could be promising novel drug candidates 9.
Molecules | October 2017 - Browse Articles
In the present communication, we report the reaction of various acetophenone derivatives with different aromatic aldehyde derivatives to form chalcones. The structures of the various synthesized compounds were assigned on the basis of IR, 1H-NMR spectral data and elemental analysis. These compounds were also screened for their antimicrobial activity. Chalcone constitute an impartment group of natural products and some of them possess a wide range of biological activities such as antimicrobial 1 anticancer 2 antitubercular 3.
Molecules, an international, peer-reviewed Open Access journal.
Shaebanzadeh, "Synthesis and characterization of new 3,5-dinaphthyl substituted 2-pyrazolines an study of their antimicrobial activity" Molecules 7, 885-895, 2002 .
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