TIB Archives / Hannover University Archives
Tewari and colleagues synthesized a novel series of 1,3,5-trisubstituted pyrazoles ..
Synthesis of 1-substituted 3,5-diaryl-2-pyrazolines by …
Saraf , Facile One-Pot Synthetic Methodologies For Nitrogen Containing Heterocyclic Derivatives Of 3,5-Disubstituted 4,5-Dihydro-1h-Pyrazole, Their Biological Evaluation And Molecular Docking Studies, Accepted in Pharmaceutical Chemistry Journal (Paper No.-3018; ISSN: 1573-9031), 2015.(Springer, Impact Factor-0.452)
Abstract Tetraoxaquines, molecular hybrids of 1,2,4,5-tetraoxane and 4-aminoquinoline, were designed via molecular docking analysis against Falcipain-2. Among the studied compounds, 11 top scoring analogues showing low binding energy were further selected for synthesis and evaluated for their in vitro antimalarial activity. In inhibitory assay, five compounds showed significant activity against chloroquine-resistant strain of P. falciparum -RKL-9 with IC 50 values of 3.906, 3.942, 4.272, 3.906, 4.814 µg/ml. (Source: Medicinal Chemistry Research)
4,5-Dihydro-1H-pyrazole: an indispensable scaffold ..
Saraf, Syntheses Characterization and Antimicrobial Evaluation of Some 1, 3, 5-trisubstituted Pyrazole Derivatives; E-Journal Of Chemistry (ISSN: 0973-4945): 7(4), 1190-1195, 2010.
Saraf, Syntheses, characterization and evaluation of some 1,3,4-tri substituted-5-pyrazolone derivatives as dual anti-inflammatory and antimicrobial agents, Der Pharmacia Sinica (ISSN: 0976-8688) ; 3(5), 546-555, , 2012.
evaluation of some novel 1,3,5-trisubstituted ..
Anna Pratima G Nikalje, Gaurav Gaikwad, Rajesh Nawale, Jaiprakash Sangshettiand Firoz A Khan,
"Synthesis, Pharmacological Evaluation and Docking Study of Novel 3-Phenyl-5-Aryl-4, 5-Dihydro-1h-Pyrazole-1-Carbaldehydeas Anti-Inflammatory Agents"
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6(2),423-431,(2015)
Saraf, Synthesis of 1, 3, 5-Trisubstituted Pyrazoline nucleus containing compounds and screening for Anti-microbial activity, Medicinal Chemistry Research (ISSN: 1054-2523): 21(11), 3376-3381, 2012.
and evaluation of novel thiazoles for potent antidiabetic activity
Synthesis of 2-(5-(1H-indol-3 ..
derivatives of 3,4,5-trisubstituted pyrazoles.
Articles Accepted - Indiandrugsonline
13/03/2009 · ..
25/12/2017 · A series of 2-pyrazolines 5– 9 have ..
Pyrazoline bearing benzimidazoles were synthesized by M. Shaharyar et al 66 and evaluated for anticancer activity. Compounds (4n) was found to be the most active candidate of the series. A.H. Banday et al 67 reported the synthesis of 17-pyrazolinyl derivatives of pregnenolone (4o) and their evaluation as potential anticancer agents against various human cancer cell lines. Various compounds showed significant cytotoxic activity against HT-29, HCT-15, 502713 cell lines.
Microwave-Assisted Synthesis of Some 1,3,4-Oxadiazole ..
1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide (4l) were synthesized by R. Bashir et al 64 and evaluated for antitumor activity. Compounds exhibited considerable antitumor activities against the entire tested tumor cell lines.
Thieme E-Journals - Drug Research / Abstract
F.M. 274 Awadallah et al 59 synthesized pyrazolinyl-dihydropyrimidine derivatives and were investigated for their antiproliferative activity against A 549 (lung), HT 29 (colon), MCF 7and MDA-MB 231 (breast) cell lines. Compounds 4f and 4g, showed high activity against three of the cell lines. Derivatives with scaffolds of 1,3,5-tri-substituted pyrazoline and 1,3,4,5-tetra-substituted pyrazoline (4h) were synthesized and tested for their inhibitory effects on human tumor cell lines by M. Abdel-Halim et al 60.
synthesis, and antimalarial evaluation of thiazole ..
Mannich base of pyrazolines (7c) was synthesized by P. C. Jagadish 79 compounds were subsequently evaluated for the antioxidant activity compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin. A novel series of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines (7d) was synthesized by B. P. Bandgar et al 80 and evaluated for antioxidant activity. Most of the compounds exhibited good DPPH and superoxide radical scavenging activity.
one-pot, three-component synthesis of ..
Depression is one of the central nervous system disorder. Pyrazolines have been found to possess antidepressant potential. Some New 1,3,5-trisubstituted-2-pyrazolines (3a) were synthesized by Atla Srinivasa Rao et al 49 and evaluated for their antidepressant profile. Compound 3a showed antidepressant activity similar to standard, tranylcypromine. It was revealed that the presence of electron releasing group on phenyl ring system attached at C-5 position of 2-pyrazoline is important for their activity.
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