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Rowland and Molina persevered to prove their hypothesis, ..

But the Rowland-Molina hypothesis was strongly disputed by representatives of the aerosol and halocarbon industries.

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1974 Molina and Rowland publish their ; hypothesis in Nature.

(Several other scientists, including Ralph Cicerone, Richard Stolarski, Michael McElroy, and Steven Wofsy had independently proposed that chlorine could catalyze ozone loss, but none had realized that CFCs were a potentially large source of chlorine.) Crutzen, Molina and Rowland were awarded the 1995 Nobel Prize for Chemistry for their work on this problem.

The Rowland and Molina theory says that CFCs are so ..

But the Rowland-Molina hypothesis was strongly disputed by representatives of the aerosol and halocarbon industries. The chair of the board of was quoted as saying that ozone depletion theory is "a science fiction tale...a load of rubbish...utter nonsense". , the president of Precision Valve Corporation (and inventor of the first practical aerosol spray can valve), wrote to the Chancellor of UC Irvine to complain about Rowland's public statements (Roan, p. 56.)

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After publishing their pivotal paper in June 1974, Rowland and Molina testified at a hearing before the U.S. House of Representatives in December 1974. As a result significant funding was made available to study various aspects of the problem and to confirm the initial findings. In 1976, the U.S. (NAS) released a report that confirmed the scientific credibility of the ozone depletion hypothesis. NAS continued to publish assessments of related science for the next decade.

In 1973 Chemists and , then at the , began studying the impacts of CFCs in the Earth's atmosphere. They discovered that CFC molecules were stable enough to remain in the atmosphere until they got up into the middle of the where they would finally (after an average of 50–100 years for two common CFCs) be broken down by releasing a atom. Rowland and Molina then proposed that these chlorine atoms might be expected to cause the breakdown of large amounts of ozone (O3) in the stratosphere. Their argument was based upon an analogy to contemporary work by and , which had shown that nitric oxide (NO) could catalyze the destruction of ozone. (Several other scientists, including , Richard Stolarski, Michael McElroy, and Steven Wofsy had independently proposed that chlorine could catalyze ozone loss, but none had realized that CFCs were a potentially large source of chlorine.) Crutzen, Molina and Rowland were awarded the 1995 for their work on this problem.

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