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protein synthesis; neuron; translation; synapse; fragile X

PROTEIN SYNTHESIS

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Protein biosynthesis - Wikipedia

Martin KC, Casadio A, Zhu H et al. (1997) Synapse‐specific, long‐term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91(7): 927–938.

Protein Synthesis - Department of Chemistry

Casadio A, Martin KC, Giustetto M et al. (1999) A transient, neuron‐wide form of CREB‐mediated long‐term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99(2): 221–237.

Proteins are synthesized in the cell's ribosomes

Alterations of neuronal protein synthesis in humans can cause a variety of behavioural, cognitive and memory deficits.

It is also known that the proteins synthesised by the herpes simplex virus infected cells contain more arginine but less lysine, methionine, phenylalanine, tryrosine, and isoleucine relative to leucine than the proteins synthesised by unaffected cells.

L-lysine 390 mg.

It is an extension of the outer membrane of the nuclear envelope, so allowing mRNA to be transported swiftly to the 80s ribosomes, where they are translated in protein synthesis

Translation: Making Protein Synthesis Possible

Neurons are immensely complex cells whose morphology and physiology underpin our cognition. Achieving proper neuronal connections during development, as well as eliciting appropriate responses to environmental stimuli in the adult, requires precisely regulated protein synthesis. To meet these requirements, neurons have adapted regulatory mechanisms that act at every step in the process of producing functional proteins. Many of these mechanisms target messenger ribonucleic acid (mRNA)‐binding proteins and ribosomal subunits to regulate translational initiation. These mechanisms are especially concentrated at synapses, where they act to transform transient electrical signals into lasting functional modifications that are a basis for learning and memory. Misregulated synaptic protein synthesis contributes to several human cognitive changes including addiction, fragile X syndrome and autism.

Neurons exhibit extensive and compartmentalised arbours of axons and dendrites, which place unique demands on the timing and location of protein synthesis.

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  • where are the proteins synthesized in the cell

    Messenger RNA It carries a genetic message from the DNA to the protein-synthesizing machinery of the cell.

  • Where Are Proteins Synthesized ..

    How are proteins synthesized

  • Protein Synthesis -Translation and Regulation

    Protein Synthesis

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Protein Synthesis - Notes - Biology | Mrs. McComas

Growth cones are specialised structures that guide developing axons and dendrites to their targets. Extracellular guidance cues regulate local protein synthesis in growth cones to guide axons and dendrites to their destination.

Goal 2 - Protein Synthesis Notes

In the adult brain, neurons rapidly communicate through specialised contacts called synapses. The strength of communication at a synapse can be modified as a function of its past use. These changes are mediated, in part, by the local protein synthesis at the synapse.

The building of proteins is called protein synthesis

Biochemical networks called signal transduction pathways convert specific patterns of synaptic transmissions into new protein synthesis. Ribosomal and RNA‐binding proteins are common targets of these pathways.

Where are proteins synthesised inside the cell

Frey U, Krug M, Reymann KG and Matthies H (1988) Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Research 452(1–2): 57–65.

bio final exam protein synthesis Flashcards | Quizlet

Huber KM, Kayser MS and Bear MF (2000) Role for rapid dendritic protein synthesis in hippocampal mGluR‐dependent long‐term depression. Science 288(5469): 1254–1257.

Protein Synthesis Concept Map by Akila Jayawardane on Prezi

Oppenheim RW, Prevette D, Tytell M and Homma S(1990) Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Developmental Biology 138(1): 104–113.

Protein Synthesis in Neurons - eLS: Essential for Life Science

Osterweil EK, Krueger DD, Reinhold K and Bear MF (2010) Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. Journal of Neuroscience 30(46): 15616–15627.

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