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Protein - definition of protein by The Free Dictionary

T1 - Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker

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Ribosomes - Protein Synthesis - Cronodon

For example, stable-isotope labeled protein samples can be produced on a milligram scale through cell-free synthesis, which is useful for NMR analysis.

T1 - Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN

AB - The suprachiasmatic nucleus (SCN) of the hypothalamus contains a circadian pacemaker that regulates many circadian rhythms in mammals. Experimental work in microorganisms and invertebrates suggests that protein synthesis is required for the function of the circadian oscillator, and recent experiments in golden hamsters suggest an acute inhibition of protein synthesis can induce phase shifts in a mammalian circadian pacemaker. To determine whether protein synthesis in the SCN region is involved in the generation of circadian rhythms in mammals, a protein synthesis inhibitor, anisomycin, was microinjected into the SCN region, and the effect on the circadian rhythm of locomotor activity of hamsters was measured. A single injection of anisomycin into the SCN region induced phase shifts in the circadian activity rhythm that varied systematically as a function of the phase of injection within the circadian cycle. These results suggest that protein synthesis may be involved in the generation of circadian rhythms in mammals and that the anatomic site of action of anisomycin is within the hypothalamic suprachiasmatic region.

Mechanism of Protein Synthesis (Explained With Diagram)

A standardized method has been established for high-yield cell-free protein synthesis using E.

AB - Administration of the protein synthesis inhibitor, anisomycin, induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in hamsters maintained in constant darkness. The magnitude and direction of the phase shift was dependent on the circadian time of drug treatment. A second protein synthesis inhibitor, cycloheximide, also induced phase-shifts in the circadian rhythm of activity, while two drugs which mimic some of the side effects of protein synthesis inhibitors had no significant effect on the activity rhythm. The phase-response curve generated by anisomycin injections in the hamster is similar to the response curves that have been measured for protein synthesis inhibitors in micro-organisms and invertebrates. Thus, the biochemical mechanisms generating circadian oscillations in mammals may share common features with those found in very distantly related phylogenetic groups.

N2 - The suprachiasmatic nucleus (SCN) of the hypothalamus contains a circadian pacemaker that regulates many circadian rhythms in mammals. Experimental work in microorganisms and invertebrates suggests that protein synthesis is required for the function of the circadian oscillator, and recent experiments in golden hamsters suggest an acute inhibition of protein synthesis can induce phase shifts in a mammalian circadian pacemaker. To determine whether protein synthesis in the SCN region is involved in the generation of circadian rhythms in mammals, a protein synthesis inhibitor, anisomycin, was microinjected into the SCN region, and the effect on the circadian rhythm of locomotor activity of hamsters was measured. A single injection of anisomycin into the SCN region induced phase shifts in the circadian activity rhythm that varied systematically as a function of the phase of injection within the circadian cycle. These results suggest that protein synthesis may be involved in the generation of circadian rhythms in mammals and that the anatomic site of action of anisomycin is within the hypothalamic suprachiasmatic region.

Mechanism of Protein Synthesis (Explained With Diagram) ..

These applications are necessary to support high-throughput protein preparation.

N2 - Administration of the protein synthesis inhibitor, anisomycin, induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in hamsters maintained in constant darkness. The magnitude and direction of the phase shift was dependent on the circadian time of drug treatment. A second protein synthesis inhibitor, cycloheximide, also induced phase-shifts in the circadian rhythm of activity, while two drugs which mimic some of the side effects of protein synthesis inhibitors had no significant effect on the activity rhythm. The phase-response curve generated by anisomycin injections in the hamster is similar to the response curves that have been measured for protein synthesis inhibitors in micro-organisms and invertebrates. Thus, the biochemical mechanisms generating circadian oscillations in mammals may share common features with those found in very distantly related phylogenetic groups.

Administration of the protein synthesis inhibitor, anisomycin, induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in hamsters maintained in constant darkness. The magnitude and direction of the phase shift was dependent on the circadian time of drug treatment. A second protein synthesis inhibitor, cycloheximide, also induced phase-shifts in the circadian rhythm of activity, while two drugs which mimic some of the side effects of protein synthesis inhibitors had no significant effect on the activity rhythm. The phase-response curve generated by anisomycin injections in the hamster is similar to the response curves that have been measured for protein synthesis inhibitors in micro-organisms and invertebrates. Thus, the biochemical mechanisms generating circadian oscillations in mammals may share common features with those found in very distantly related phylogenetic groups.

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    T1 - Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker

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Protein Synthesis vs Protein Production - BiologicsCorp

Administration of the protein synthesis inhibitor, anisomycin, induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in hamsters maintained in constant darkness. The magnitude and direction of the phase shift was dependent on the circadian time of drug treatment. A second protein synthesis inhibitor, cycloheximide, also induced phase-shifts in the circadian rhythm of activity, while two drugs which mimic some of the side effects of protein synthesis inhibitors had no significant effect on the activity rhythm. The phase-response curve generated by anisomycin injections in the hamster is similar to the response curves that have been measured for protein synthesis inhibitors in micro-organisms and invertebrates. Thus, the biochemical mechanisms generating circadian oscillations in mammals may share common features with those found in very distantly related phylogenetic groups.

h bio protein synthesis test Flashcards | Quizlet

The suprachiasmatic nucleus (SCN) of the hypothalamus contains a circadian pacemaker that regulates many circadian rhythms in mammals. Experimental work in microorganisms and invertebrates suggests that protein synthesis is required for the function of the circadian oscillator, and recent experiments in golden hamsters suggest an acute inhibition of protein synthesis can induce phase shifts in a mammalian circadian pacemaker. To determine whether protein synthesis in the SCN region is involved in the generation of circadian rhythms in mammals, a protein synthesis inhibitor, anisomycin, was microinjected into the SCN region, and the effect on the circadian rhythm of locomotor activity of hamsters was measured. A single injection of anisomycin into the SCN region induced phase shifts in the circadian activity rhythm that varied systematically as a function of the phase of injection within the circadian cycle. These results suggest that protein synthesis may be involved in the generation of circadian rhythms in mammals and that the anatomic site of action of anisomycin is within the hypothalamic suprachiasmatic region.

Help! What is Protein Synthesis? | Yahoo Answers

N2 - Administration of the protein synthesis inhibitor, anisomycin, induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in hamsters maintained in constant darkness. The magnitude and direction of the phase shift was dependent on the circadian time of drug treatment. A second protein synthesis inhibitor, cycloheximide, also induced phase-shifts in the circadian rhythm of activity, while two drugs which mimic some of the side effects of protein synthesis inhibitors had no significant effect on the activity rhythm. The phase-response curve generated by anisomycin injections in the hamster is similar to the response curves that have been measured for protein synthesis inhibitors in micro-organisms and invertebrates. Thus, the biochemical mechanisms generating circadian oscillations in mammals may share common features with those found in very distantly related phylogenetic groups.

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