Mesoporous calcium silicate glasses
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It is of great importance to prepare multifunctional scaffolds combining good mechanical strength, bioactivity, and drug delivery ability for bone tissue engineering. In this study, nanosized mesoporous bioglass/poly(lactic-co-glycolic acid) composite-coated calcium silicate scaffolds, named NMBG-PLGA/CS, were successfully prepared. The morphology and structure of the prepared scaffolds were characterized by scanning electron microscopy and X-ray diffraction. The effects of NMBG on the apatite mineralization activity and mechanical strength of the scaffolds and the attachment, proliferation, and alkaline phosphatase activity of MC3T3 cells as well as drug ibuprofen delivery properties were systematically studied. Compared to pure CS scaffolds and PLGA/CS scaffolds, the prepared NMBG-PLGA/CS scaffolds had greatly improved apatite mineralization activity in simulated body fluids, much higher mechanical property, and supported the attachment of MC3T3 cells and enhanced the cell proliferation and ALP activity. Furthermore, the prepared NMBG-PLGA/CS scaffolds could be used for delivering ibuprofen with a sustained release profile. Our study suggests that the prepared NMBG-PLGA/CS scaffolds have improved physicochemical, biological, and drug-delivery property as compared to conventional CS scaffolds, indicating that the multifunctional property of the prepared scaffolds for the potential application of bone tissue engineering.
Studies have focused on the bioactive composites created by combining biodegradable polymers and bioactive inorganic materials such as bioglass, calcium phosphate, and silicate., However, to our knowledge, there has been no report about the preparation of mesoporous magnesium silicate (m-MS) and PCL-PEG-PCL bioactive composite for use as bone repair material. It is expected that the biological performance of polymer-based bioactive composite should be improved if m-MS were incorporated into PCL-PEG-PCL. Therefore, in this study, m-MS/PCL-PEG-PCL bioactive composite (m-MPC) was prepared, and the effects of m-MS content on hydrophilicity, degradability, and apatite formation in vitro and cell attachment and proliferation on the bioactive composite were investigated.
Regional Centre of Advanced Technologies and Materials
Nanosized mesoporous bioactive glass (NMBG) powders were synthesized using cetyltrimethylammonium bromide (CTAB) as template, in which 6.6g CTAB was firstly dissolved in 600mL of distilled water with 12mL of ammonia water. After stirring for 1h at 37°C, 30mL tetraethyl orthosilicate (TEOS) and 31.21g Ca(NO3)2·4H2O were added to the solution and stirred for 6h. The products were collected by vacuum filtration and washed by distilled water and ethanol for 3 times. Ethanol mixed with 1% HCl solution was used to wash the powders to remove CTAB. After dried at 60°C for 24h, the powders were calcined at 550°C for 2h. The NMBG powders were characterized by X-ray diffraction (XRD) (D/Max 2550V, Rigaku Japan), scanning electron microscopy (SEM) (JSM-6700, JEOL, Japan), and transmission electron microscopy (TEM) (2100F, JEOL, Japan). The specific surface area, mesopore size distribution, and pore volume were determined by N2 adsorption-desorption isotherms (Micromeritics Tristar 3000).
Researche institute in Czech Republic focuses on nanotechnology
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Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry
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