Clandestine methcathinone (ephedrone) synthesis …
ephedrine can be easily synthesized into methcathinone
+ * Synthesis of Ephedrine & Methcathinone from Propionic Acid
Simple derivatives such as methcathinone and -dimethylcathinone can be synthesised by oxidation of ephedrine (or pseudoephedrine) and-methylephedrine (or -methylpseudoephedrine) respectively. This requires reacting the precursor with a solution of potassium permanganate in dilute sulfuric acid. The precursors can be obtained as specific enantiomers, thereby ensuring that the synthesis is stereoselective. Cathinone itself can be made in a similar way, starting from phenylpropanolamine (norephedrine). One of the hazards of the permanganate process is that users can suffer manganese poisoning if the product is not purified.
It is advisable to become familiar with the many ways of synthesizing methcathinone from (pseudo)ephedrine, as just such a procedure can be used on freshly produced methamphetamine to verify that the (pseudo)ephedrine was in fact reduced.
Methcathinone - an overview | ScienceDirect Topics
In clandestine laboratories, synthesizing methcathinone using potassium permanganate is considered undesirable because of the low yields and the high toxicity of this oxidant. A method that yields more methcathinone is oxidizing (pseudo)ephedrine with compounds. If done in a proper laboratory using the proper procedures, however, potassium permanganate can be a high-yielding reactant.
Methcathinone possesses a atom, and therefore enantiomers are possible. When it is made semi-synthetically from pseudo/ephedrine as a starting material, then only a single enantiomer is produced. Given that the chiral center is adjacent to the carbonyl group, the molecule will in solution.
Methcathinone | Chromium | Hydrochloric Acid
StimulantsUnless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation that contains any quantity of the following substances having a stimulant effect on the central nervous system, including their salts, isomers, and salts of isomers: Aminorex (some other names: aminoxaphen; 2-amino-5-phenyl-2-oxazoline; or 4,5-dihydro-5-phenyl-2-oxazolamine); Fenethylline; (+/-)cis-4-methylaminorex ((+/-)cis-4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine); N-ethylamphetamine; N,N-dimethylamphetamine (also known as N,N-alpha-trimethyl-benzeneethanamine; N,N-alpha-trimethylphenethylamine); N-methyl-1-(thiophen-2-yl) propan-2-amine (Methiopropamine); Substituted cathinones - any compound except bupropion or compounds listed under a different schedule, structurally derived from 2-aminopropan-1-one by substitution at the 1-position with either phenyl, naphthyl, or thiophene ring systems, whether or not the compound is further modified in any of the following ways: By substitution in the ring system to any extent with alkyl, alkylenedioxy, alkoxy, haloalkyl, hydroxyl, or halide substituents, whether or not further substituted in the ring system by one or more other univalent substituents; By substitution at the 3-position with an acyclic alkyl substituent; By substitution at the 2-amino nitrogen atom with alkyl, dialkyl, benzyl, or methoxybenzyl groups; By inclusion of the 2-amino nitrogen atom in a cyclic structure.Examples of substituted cathinones include, but are not limited to, methylone (3,4-methylenedioxymethcathinone), MDPV (3,4-methylenedioxypyrovalerone), mephedrone (4-methylmethcathinone), 4-methoxymethcathinone, 4-fluoromethcathinone, 3-fluoromethcathinone, Pentedrone (2-(methylamino)-1-phenyl-1-pentanone), pentylone (1-(1,3-benzodioxol-5-yl)-2-(methylamino)-1-pentanone), 2-(1-pyrrolidinyl)-1-(4-methylphenyl)-1-propanone, alpha-PVP (1-phenyl-2-(1-pyrrodinyl)-1-pentanone), cathinone (2-amino-1-phenyl-1-propanone), and methcathinone (2-(methylamino)-propiophenone).SCHEDULE II Narcotics-opium and opium derivativesUnless specifically excepted under federal drug abuse control laws or unless listed in another schedule, any of the following substances whether produced directly or indirectly by extraction from substances of vegetable origin, independently by means of chemical synthesis, or by a combination of extraction and chemical synthesis: Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate, excluding apomorphine, thebaine-derived butorphanol, dextrorphan, nalbuphine, nalmefene, naloxone, and naltrexone, and their respective salts, but including the following: Raw opium; Opium extracts; Opium fluid extracts; Powdered opium; Granulated opium; Tincture of opium; Codeine; Ethylmorphine; Etorphine hydrochloride; Hydrocodone; Hydromorphone; Metopon; Morphine; Oxycodone; Oxymorphone; Thebaine.
Synthetic cathinones are related to the parent compound cathinone (Figure 1), one of the psychoactive principals in ( Forsk). Cathinone derivatives are the β-keto (βk) analogues of a corresponding . The group includes several substances that have been used as of medicinal products, e.g. amfepramone (diethylpropion; Figure 2). Since the mid-2000s, unregulated ring-substituted cathinone derivatives have appeared in the European recreational drugs market. The most commonly available cathinones sold on the recreational market in the period up to 2010 appear to be mephedrone (Figure 3) and methylone (Figure 4). These products are usually encountered as highly pure white or brown powders. Ring-substituted cathinone derivatives are claimed to have effects similar to those of , or (ecstasy), but little is known of their detailed pharmacology. Apart from cathinone (Figure 1), methcathinone (Figure 5) and two ’s amfepramone (Figure 2) and pyrovalerone, cathinone derivatives are not under international control.
Both ephedrine hydrochloride and sulfate can be used in this reaction
the so-called stimulant or bronchodilator ..
2522895 Methcathinone Synthesis 2
2522894 Methcathinone Synthesis 1 - SlideShare
Ephedrine is a medication and stimulant
Chlorine gas reduces secondary alcohols to ketones and releases HCl, and primary alcohols to aldehydes
Pseudoephedrine Monograph for Professionals - …
Through oxidation, ephedrine can be easily synthesized into methcathinone. Ephedrine is listed as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
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