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Statins Inhibit Coenzyme Q10 Synthesis. - Cholesterol

Borderline high cholesterol--Total level is between 200 and 239 mg/dL or LDL is 130 to 159 mg/dL.

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CoQ 10 shares a biosynthetic pathway with cholesterol

In addition, an HDL level less than 35 mg/dL is considered low and increases the risk of heart disease.
The main goal of cholesterol treatment is to lower LDL in people without heart disease.

However, levels of CoQ10 in tissue of the brain, heart and pancreas do decrease with age.

In addition to playing a role in thyroid and adrenal health, CoQ10 is also important for the optimal health of other areas of the body. There are many studies which talk about the role of CoQ10 in cardiac disease and hypertension. One study mentioned that significant improvement has been observed in clinical and hemodynamic parameters and in exercise tolerance in patients given adjunctive CoQ10 in doses from 60 to 200 mg daily in the various trials conducted in patients of heart failure, hypertension, ischemic heart disease and other cardiac illnesses . The same study stated that CoQ10 has been found to be an independent predictor of mortality in congestive heart failure. Another study demonstrated that the addition of coenzyme Q10 to conventional therapy significantly reduces hospitalization for worsening of heart failure and the incidence of serious complications in patients with chronic congestive heart failure . Yet another study showed that Coenzyme Q10 administered orally has favorable actions in the described cardiovascular conditions and appears to be safe and well tolerated in the adult population . However, the same study warned us that CoQ10 should not be recommended as monotherapy or first-line therapy in any disease state. With regards to high blood pressure, one study concluded that CoQ10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects .

The Synthesis of Cholesterol. - Cholesterol-And …



CoQ10 might help reverse side effects caused by "statins," drugs used to lower high cholesterol, although this has not been well established due to conflicting results.

Since is localized in the Golgi compartment, this enzyme might be a nonmitochondrial CoQ10 prenyltransferase. To test this, laboratories performed subcellular fractionation experiments on human ECs and detected only in Golgi compartments and not in mitochondria.
Studies about de novo CoQ10 synthesis in these subcellular fractions by incubating ECs with the hydroxy-4-benzoic acid- 13 C 6 precursor and observed a decrease in CoQ10- 13 C 6
production in Golgi compartments compared to mitochondrial fractions when expression is reduced.
These data indicate that is a CoQ10 biosynthetic enzyme located in the Golgi membrane compartment where large amounts of cellular CoQ10 are normally synthesized.

Since CoQ10 and cholesterol are both ..

While thyroid hormone levels have an important role in modulating CoQ10 levels, some studies also show evidence that the adrenals can play a role in CoQ10 production. One study showed that CoQ10 levels were significantly lower in isolated hypoadrenalism than in patients with adrenal hyperplasia and multiple pituitary deficiencies . The same study concluded that secretion of adrenal hormones in some way relate to CoQ10 levels.

A study among middle aged people in China with high cholesterol levels who were taking statins or other cholesterol-lowering drugs found that 60 mg of CoQ10 taken twice daily after meals (120 mg per day) for 5 ½ months decreased LDL cholesterol and triglyceride levels, although not total cholesterol levels, compared to placebo.

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  • Dr. Duane Graveline on Cholesterol and Coenzyme Q10 (CoQ10)

    The level of CoQ10 in human organs peaks around the age of 20 years and then declines fairly rapidly.

  • squalene synthetase for the synthesis of cholesterol; ..

    It has been shown that Guggul can lower blood cholesterol by 14-27% and can lower triglycerides by 22-30%.

  • Cholesterol: Synthesis, Metabolism, Regulation

    Statins, the cholesterol-lowering drug prescribed to a large share of those over 40, also lower the body's CoQ10 levels

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which is a precursor for both cholesterol and CoQ10.

( ) contains an UbiA prenyltransferase domain also present in vertebrate
Although encodes a mitochondrial prenyltransferase, this new enzyme resides in the Golgi compartment where it produces CoQ10. While the presence of CoQ10 in nonmitochondrial membranes was previously explained by the existence of specific mechanisms for its redistribution within the cell, now formally studies demonstrate that CoQ10 are synthetized in the Golgi compartment.
In favor of these hypothesis of a Golgi-synthetized CoQ10, it has been reported that and which are critical enzymes for CoQ10 maturation, are also localized in the Golgi compartment. ( )

CoQ10 shares a biosynthetic pathway with cholesterol

Garcinia not only inhibits conversion of excess calories to body fat but also suppresses appetite by promoting synthesis of glycogenis a very effective herbal medicine for controlling obesity and cholesterol.
National Heart Lung and Blood Institute

Center for Medical Consumers article by Dr.

LDL cholesterol oxidation and increasing HDL- cholesterol levels

From the laboratories of the Department of Molecular Biotechnology and Health Sciences( Molecular Biotechnology Center, University of Torino) It has been identfied (a vertebrate CoQ10 prenyltransferase),as an enzyme for CoQ10 synthesis at the level of Golgi membranes, critical for oxidative stress protection (in particular, protects cardiovascular tissues from eNOS-dependent oxidative stress.
It had been found out a functional link between CoQ10, and NO signaling during cardiovascular development and homeostasis. ( )

How Cholesterol-lowering Statin Drugs Can Interfere …

Exercise and physical activity
The Effects Of Coenzyme Q10 Supplementation on Performance During Repeated Bouts of Supramaximal Exercise in Sedentary Men.
J Strength Cond Res. 2009.
The objective of this study was to determine the effects of oral coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise. This randomized, double-blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.d CoQ10 or placebo. Fifteen healthy and sedentary men participated in the study. According to our results, CoQ10 may show performance-enhancing effects during the repeated bouts of supramaximal exercises and CoQ10 might be used as ergogenic aid.
Heart Attacks
In a small trial of patients with recent myocardial infarction, Coenzyme Q10 -- used in addition to aspirin and cholesterol-lowering drugs -- decreased the likelihood of further cardiac events for at least one year after the heart attack. The dosage of Coenzyme Q10 used in the study was 60 mg twice daily.
Heart Failure.

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