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Zinc oxide nanoparticles were synthesized using a ..

Keywords: stem cells, superparamagnetic iron oxide nanoparticles, labeling, tracking, magnetic resonance imaging.

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Magnetic Iron Oxide Nanoparticles: Synthesis and …

Three types of nanoparticles were studied: nano silver (nano-Ag), nano TiO2 (nano-TiO2), and carbon nanotubes (CNT)...Exposure modeling shows that the expected concentrations of different engineered nanoparticles in the environment are strongly determined by product life cycles.

A Bioinspired Coprecipitation Method for the Controlled Synthesis of Magnetite Nanoparticles

107. Lee CM, Jeong HJ, Kim EM, Kim DW, Lim ST, Kim HT. . Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo. 2009;62:1440-6

Iron oxide nanoparticle - Wikipedia

106. Jayapaul J, Hodenius M, Arns S, Lederle W, Lammers T, Comba P. . FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells. 2011;32:5863-71

123. Yu MK, Kim D, Lee IH, So JS, Jeong YY, Jon S. Image-Guided Prostate Cancer Therapy Using Aptamer-Functionalized Thermally Cross-Linked Superparamagnetic Iron Oxide Nanoparticles. 2011;7:2241-9

Superparamagnetic Iron Oxide Nanoparticles as MRI …

58. Ling Y, Wei K, Luo Y, Gao X, Zhong S. Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy. 2011;32:7139-50

52. Hadjipanayis CG, Machaidze R, Kaluzova M, Wang L, Schuette AJ, Chen H. . EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. 2010;70:6303-12

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  • Coprecipitation-A simple method to produce …

    T1 - Size-controlled synthesis and characterization of Fe3O4 nanoparticles by chemical coprecipitation method

  • In chemistry, coprecipitation ..

    21/11/2009 · Synthesis of nickel zinc iron nanoparticles by coprecipitation technique

  • Formation Pathways of Magnetite Nanoparticles by …

    Thermogravimetric and magneticproperties of Ni 1-X Zn x Fe 2 O 4 nanoparticles synthesized by coprecipitation

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Synthesis of Ni 1-x Zn x Fe 2 O 4 nanoparticles

Three parameters were varied to optimize tumor targeting: the shape of the nanoparticle, the type of the targeting ligand, and the nature of the molecular linker. Two types of surface linkers were used to attach the targeting groups to the magnetic NWs or NSs. A short hydrocarbon places the targeting peptide (either F3 or CREKA, green lines) in close proximity to the dextran-coated nanostructure. A 5 kDa PEG linker places the targeting peptide further from the surface. The number of targeting groups per NW was varied to maximize the circulation time and optimize the tumor-targeting efficiency. These linker chemistries were tested on magnetic NSs. The NWs consisted of several NS cores linked together in a chain. Reproduced with permission from ref. [].

Formation Pathways of Magnetite …

The role of nanoparticle geometry in tumor targeting has received relatively little attention, although it is important for determining the binding affinity for a target cell. Sailor . systemically optimized tumor targeting by varying the nanomaterial shape (elongated versus spherical), targeting ligand type (cell surface targeting versus extracellular matrix targeting), ligand surface coverage, and attachment chemistry (Figure ) []. They prepared two types of tumor-targeting peptides (F3 or CREKA) and conjugated the peptides to magnetic nanoworms (NWs) or magnetic nanospheres (NSs) at varying numbers of targeting peptides and for varying PEG lengths. Intravenous injection of the magnetic nanostructures in the tumor xenograft mice models revealed that the tumor-targeting properties of the NWs were superior to those of the NSs due to multivalent interactions between the elongated NWs and the receptors on the tumor cell surfaces. The smaller neutral CREKA targeting moiety was more effective than the larger positively charged F3 targeting moiety, presumably because multiple copies of the highly cationic F3 caused a large increase in the surface charge on the particles, which facilitated clearance by the MPS-related organs. The most effective number of CREKA peptides was 60 per NW. Above 60 peptides per NW, the blood circulation time decreased. For a given number of peptides bound to the NWs, the presence of a PEG linker facilitated peptide targeting by reducing conformational restriction as well as increasing the residence time of the nanostructures in the blood stream. The short SMCC linker restricted the targeting peptide conformation. These results suggest some design guidelines for the development of targeted multifunctional nanoparticle systems for cancer imaging and therapy.

PVA assisted coprecipitation synthesis and ..

45. Das M, Mishra D, Dhak P, Gupta S, Maiti TK, Basak A. . Biofunctionalized, Phosphonate-Grafted, Ultrasmall Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Multimodal Imaging. 2009;5:2883-93

Journal of Chemistry - Hindawi Publishing Corporation

In addition to organic coatings, core-shell structures, such as biocompatible silica- or gold-covered magnetic nanoparticles, have provided an attractive approach to developing stealth nanoparticles. Silica shells serve as protective stable nanoparticle coatings under aqueous conditions. The ability to encapsulate functional molecules within the nanoparticle matrix is a unique feature of these nanostructures. Hyeon and Moon developed Fe3O4 nanocrystal-embedded, core-shell mesoporous silica nanoparticles, and they demonstrated their multifunctional application to simultaneous MR/optical imaging and drug delivery []. This study suggested a precise method for controlling the size of the silica nanoparticles smaller than 100 nm. The surfactant cetyltrimethylammonium bromide (CTAB) provided an organic template for the formation of a mesoporous silica shell and stabilized the hydrophobic Fe3O4 nanocrystals in an aqueous solution. The sol-gel process occurred through the template by using tetraethylorthosilicate (TEOS) and rhodamine B isothiocyanate (RITC)-labeled aminopropyltriethoxysilane (APS), and generated amine groups containing silica shell, to which PEG was covalently conjugated via succinimidyl end group to render further biocompatibility. Dox molecules loaded onto the as-synthesized Fe3O4@mSiO2(R)-PEG NPs to convey therapeutic properties. The core-shell structure exhibited magnetic and fluorescent properties, as well as a therapeutic index, suggesting the utility of the nanostructure in biomedical theranostic applications. On the other hand, gold provides several advantages as a coating material due to its inertness and its unique ability to absorb near-IR radiation. Hyeon and Cho described magnetic gold nanoshells (Mag-GNS) consisting of gold nanoshells encapsulating magnetic Fe3O4 nanoparticles as a novel nanomedical platform for simultaneous diagnostic imaging and thermal therapy []. Monodisperse 7 nm Fe3O4 nanoparticles stabilized with 2-bromo-2-methylpropionic acid (BMPA) were covalently attached to amino-modified silica spheres through a direct nucleophilic substitution reaction between the bromo groups and the amino groups. Gold seed nanoparticles were then attached to the residual amino groups of the silica spheres. Finally, a complete 15 nm thick gold shell embedded with Fe3O4 nanoparticles formed around the silica spheres to generate Mag-GNS. To target breast cancer, an anti-HER2/neu antibody was conjugated onto the surfaces of the Mag-GNS. SKBR3 breast cancer cells treated with Mag-GNS could be detected using a clinical MRI system, followed by selective destruction by near-IR radiation.

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