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BODIPY® dyes - ATDBio - Oligo synthesis experts

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02/08/2017 · BODIPY-based dye for no-wash live ..

How to cite this article: Wang, Z. et al. BODIPY-doped silica nanoparticles with reduced dye leakage and enhanced singlet oxygen generation. Sci. Rep.5, 12602; doi: 10.1038/srep12602 (2015).

Figure 1. Synthesis of fluorogenic BODIPY–prodrug M1 activatable conjugates.
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We have successfully designed and prepared a heavy atom (I) containing chromophore as well as the resulting dye-doped silica nanoparticles. An iodine free chromophore was also prepared for comparison. The results clearly demonstrated that the incorporation of heavy atoms leads to enhanced generation of singlet oxygen, which has been verified by a chemical probe method as well as a direct measurement of singlet oxygen luminescence. These nanoparticles can be successfully taken up by various tumor cells and showed phototoxicity toward the cells treated with light irradiation, demonstrating a great potential for PDT. Worth mentioning is that the iodine atom of the BODIPY can also be replaced by a radiolabeled iodine atom (e.g., I-124, I-125, etc.), and the resulting nanoparticles with their PDT functionality retained could be employed as good contrast agents for positron emission tomography imaging. Furthermore, the silica surface of the dye-doped nanoparticles is available for surface modification and bioconjugation, indicating that the presented silica NPs have a great potential in developing multifunctional therapeutic nanoplatforms.

Synthesis and Evaluation of [18F]-Ammonium BODIPY …

264. Cal PMSD, Bernardes GJL, Gois PMP. Cysteine-Selective Reactions for Antibody Conjugation.  2014;53:10585-7
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54. Yang Y, Guo Q, Chen H. . Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy. 2013;49:3940-2

37. Wang Y, Yan XP. Fabrication of vascular endothelial growth factor antibody bioconjugated ultrasmall near-infrared fluorescent Ag2S quantum dots for targeted cancer imaging . 2013;49:3324-6

BODIPY R6G Fluorescent Oligonucleotide Labeling

Approaches to the synthesis of chiral and amino-substituted BODIPY dyes: ..
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145. Dong D, Xia G, Li Z. . Human Serum Albumin and HER2-Binding Affibody Fusion Proteins for Targeted Delivery of Fatty Acid-Modified Molecules and Therapy. 2016;13:3370-80

97. Wagner S, Rothweiler F, Anhorn MG. . Enhanced drug targeting by attachment of an anti αv integrin antibody to doxorubicin loaded human serum albumin nanoparticles. 2010;31:2388-98

Carbazole substituted BODIPY dyes: Synthesis, photophysical properties and antitumor activity
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  • Synthesis of paramagnetic BODIPY dyes as ..

    BODIPY - Wikipedia

  • Recent Advances of the Near-infrared Fluorescent aza-BODIPY Dyes

    BODIPY 493/503 Staining of Neutral Lipid Droplets for Microscopy and Quantification by Flow Cytometry

  • aza-BODIPY, dye, near-infrared, ..

    Synthesis of an azabodipy dye.

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CellTracker™ Green BODIPY™ Dye - ZAGENO

AB - New, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye based thiol-reactive fluorescent label, fluorescent amino acid, and fluoroionophore compounds with 540-560 nm emission are described. Combination of a BODIPY dye with a nitronyl nitroxide or an imino nitroxide or a bifunctional pyrroline nitroxide furnished a nitric oxide, a redox sensitive molecule and a double (spin and fluorescence) label, respectively.

CellTracker™ Green BODIPY® ..

(2) Near infrared (NIR) dyes.
We are interested in the design and synthesis of soluble and stable NIR dyes with tunable physical properties and their applications for NIR laser protection, bio-imaging and dye-sensitized solar cells. Our approach is to combine the polycyclic hydrocarbons with heteroatom-containing aromatic systems such as porphyrin and BODIPYs.

Package Content CellTracker™ Green BODIPY™ Dye

Albumin is distributed all over the body blood flow, which has been utilized to determine the total blood and plasma volume in the Jeanatope and Megatope (Table ). In optimizing nanosystems, albumin requires further modification and fabrication to obtain precise diagnosis and effective drug delivery []. Various medical needs need the expansion of albumin applications in different nanosystems [].

Chemistry Seminar: When BODIPY and porphyrin work …

A novel BODIPY−doxorubicin prodrug conjugate was developed for simultaneous fluorescence cell tracking and functional modulation of proinflammatory subpopulations of macrophages .

Papers with the keyword Bodipy (Page 2) | Read by QxMD

In recent years, boron-dipyrromethene (BODIPY) and boron-azadipyrromethene (aza-BODIPY) dyes have attracted considerable multidisciplinary attention due to their diverse applications. By introducing various hydrophilic groups, such as quaternary ammonium, sulfonate or oligo-ethyleneglycol moieties into the BODIPY core, the solubilities of these dyes in aqueous solution can be greatly improved while maintaining their high fluorescence quantum yields. Accordingly, applying these fluorescent dyes in aqueous systems to areas such as chemosensors, biomacromolecule labeling, bio-imaging and photodynamic therapy has been achieved. In this article, the recent progress on the synthesis, optical properties and application of water-soluble BODIPY dyes and aza-BODIPY dyes is reviewed.

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