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Biosynthesis of Cephalosporin-C Acylase Enzyme: …

T1 - Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus

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Cephalosporin C Biosynthesis by Cephalosporium

A kinetic model describing the cephalosporin biosynthesis in Streptomyces clavuligerus was developed. Using previously reported kinetic data of biosynthetic enzymes, we examined the kinetics of cephalosporin production. The predicted time profile of the specific production rate during a batch culture parallels that of experimental observation. Sensitivity analysis reveals that δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) synthetase in the rate-limiting enzyme. The effect of amplifying ACV synthetase on the specific production rate was analyzed theoretically. Increasing ACV synthetase enhances the production rate initially until deacetoxycephalosporin C hydroxylase becomes rate-limiting. Such kinetic analysis can provide a rational basis for modifying the biosynthetic machinery of cephalosporin through gene cloning.

02/08/2010 · Biosynthesis of Cephalosporin-C Acylase Enzyme: ..

N2 - A kinetic model describing the cephalosporin biosynthesis in Streptomyces clavuligerus was developed. Using previously reported kinetic data of biosynthetic enzymes, we examined the kinetics of cephalosporin production. The predicted time profile of the specific production rate during a batch culture parallels that of experimental observation. Sensitivity analysis reveals that δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) synthetase in the rate-limiting enzyme. The effect of amplifying ACV synthetase on the specific production rate was analyzed theoretically. Increasing ACV synthetase enhances the production rate initially until deacetoxycephalosporin C hydroxylase becomes rate-limiting. Such kinetic analysis can provide a rational basis for modifying the biosynthetic machinery of cephalosporin through gene cloning.

Penicillin and cephalosporin biosynthesis

A kinetic model describing the cephalosporin biosynthesis in Streptomyces clavuligerus was developed. Using previously reported kinetic …

AB - A kinetic model describing the cephalosporin biosynthesis in Streptomyces clavuligerus was developed. Using previously reported kinetic data of biosynthetic enzymes, we examined the kinetics of cephalosporin production. The predicted time profile of the specific production rate during a batch culture parallels that of experimental observation. Sensitivity analysis reveals that δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) synthetase in the rate-limiting enzyme. The effect of amplifying ACV synthetase on the specific production rate was analyzed theoretically. Increasing ACV synthetase enhances the production rate initially until deacetoxycephalosporin C hydroxylase becomes rate-limiting. Such kinetic analysis can provide a rational basis for modifying the biosynthetic machinery of cephalosporin through gene cloning.

National Collection of Industrial Microorganisms (NCIM)

View This Abstract Online [Advances in the regulation of cephalosporin C biosynthesis - A review]. Wei Sheng Wu Xue Bao. 2016; 56(3):461-70 (ISSN: 0001-6209)

TY - JOUR. T1 - Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus. AU - Khetan,Anurag. AU - Malmberg,Li Hong. AU - Sherman,David H.
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