Synthesis of Aspirin- Why Sulphuric Acid? | Yahoo Answers
Mar 25, 2007 · What is the role of phosphoric acid in the synthesis of acetylsalicylic acid
Synthesis of Aspirin Lab procedures ..
Taken as a whole, the results indicate that WPC does protect gastric mucosa from ethanol damage and that the protection depends on sulfhydryl compounds present in the WPC, including its capacity to stimulate glutathione synthesis.
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Functions of the liver also include the synthesis of various important compounds in addition to plasma proteins. Synthesis and secretion of transferrin, globulins and other such compounds also falls under the domain of liver.
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Treating the rats with an intraperitoneal injection of butathionine sulfoximine, which inhibits glutathione synthesis, reduced WPC protection to 35% and 52% for single and double doses, respectively.
Further Analysis THE END Presented by MY LIFE: YOU LIGHT IT UP Conclusion The overall objectives of this experiment were to synthesize aspirin, to perform a crude purity test on said aspirin, to standardize and prepare solutions of both NaOH and HCL, and to qualitatively determine the purity of the aspirin by finding the percentage of acetylsalicylic acid in the aspirin.
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Taken from the University of Minnesota
Alkali Metal's IR results for salicylic acid
Difference between Salicylic Acid and Methyl Salicylate
Background of Nuclear Magnetic Resonance (NMR)
Nuclei have spin and all nuclei are electrically charged.
When an external magnetic field is applied, energy transfer is possible between the base energy & higher energy level.
Energy transfer takes place at a wavelength that corresponds to radio frequencies.
When spin returns to base level, energy is emitted at same frequency.
Protons in different electronic environments will absorb different frequencies of this radiation.
Calculations: Synthesis of Salicylic Acid from Methyl Salicylate
Mass: 1.0002 grams
Percent Yield: 70% Yield
Accepted Melting point: 159 degrees Celsius
Measured Melting point: 152 degrees Celsius
Synthesis of Aspirin from Salicylic Acid
Add acetic anhydride to salicylic acid with a few drops of sulfuric acid.
Heat, allow for recrystallization, separate by vacuum filtration.
Repeat and add ethanol and water.
Test for purity by adding 1 drop of ferric chloride
NMR spectrometers employ strong magnetic fields and the frequency of radiation typically required for nuclear resonance falls in the radio wave region of the electromagnetic spectrum.
Difference between Salicylic Acid and Aspirin
Experimentally-Obtained NMR of Aspirin
Left: Crude aspirin
Middle: Aspirin after purification
Right: Pure salicylic acid
IR Spectra of Salicylic Acid
Lab technique used to learn about the composition of a substance.
Measures absorption of visible & UV light by bonds of organic compounds
Different atom conformations absorb different wavelengths of light
Determines molecular structure by which wavelengths are absorbed
Used to identify molecules & test for purity
Experimentally-Obtained IR Spectra
Experimental Comparison of Aspirin and Salicylic Acid
Comparison of Aspirin and Salicylic Acid
Used to test for purity of synthesized aspirin sample
Sent wavelength absorbed well by salicylic acid but not well by aspirin
Compared absorption by pure salicylic standards to absorption of aspirin sample
Plotted best fit absorption line based off of salicylic acid samples
Used the line’s equation to calculate amount of salicylic acid in aspirin sample
Results indicate our aspirin had .89% salicylic acid mixed in
Experimentally-Obtained IR Spectra of Aspirin
UV/vis in Aspirin Synthesis
Alkali Metal's IR results for Aspirin
"Institute for Protein Research, Osaka University." Institute for Protein Research, Osaka University.
Ryu, their Teacher Assistants: Anke, Bri, Greg, Joe Nailah, and Glyftawlbnz (Casey)
Synthesize aspirin from a non- petroleum source
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Background of IR Spectroscopy
Used to determine purity of compound by analyzing to which degree bonds absorb IR radiation
Quantization of energy allows for absorption of specific energy levels of bonds
Wavenumbers are representative of the energy levels
% transmittance measures to what degree the absorption occurs
Vibrational energy turns into bending and stretching
The Alkali Metals
Synthesis of Aspirin
Common Medical Applications
Negative Side Effects
Synthesis of Salicylic Acid
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Synthesis of Salicylic Acid from Methyl Salicylate
Add 6 M NaOH into a boiling flask that contains methyl salicylate.
With H2O flowing in
heat reaction mixture under reflux for 30 minutes.
Transfer to beaker, add H2SO4
Cool mixture and collect salicylic acid via
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Liver enzymes help speed up chemical reactions in the liver.
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Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry
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