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Inhibition of protein synthesis4.

2004, Protein Synthesis and Ribosome Structure, Nierhaus, K.H., Wilson, D.N.

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Inhibition of Protein Synthesis by Antibiotics | Sigma-Aldrich

Hallock S, Tang SC, Buja LM et al. (2007) Aurintricarboxylic acid inhibits protein synthesis independent, sanguinarine‐induced apoptosis and oncosis. Toxicological Pathology 35: 300–309.

Introduction The pathway of bacterial protein synthesis is directed by ribosomes in conjunction...

Vannuffel Histology Department, University of Louvain, Medical School, Brussels 1200, Belgium The streptogramins and related antibiotics (the lincosamides and macrolides) (MLS) are important inhibitors of bacterial protein synthesis.

Inhibition of Protein Synthesis ..

Brandi L, Fabbretti A, Pon CL, Dahlberg AE and Gualerzi CO (2008b) Initiation of protein synthesis: a target for antimicrobials. Expert Opinion on Therapeutic Targets 12: 519–534.

Wilson DN and Nierhaus KH (2006) The E‐site story: the importance of maintaining two tRNAs on the ribosome during protein synthesis. Cellular and Molecular Life Sciences 63: 2725–2737.

Protein synthesis inhibitor - Wikipedia

Schallmey 21, isolated soil bacteria which shows antibiotic activity under normal growth condition and was found inhibiting some gram positive and some gram negative organism both Bacillus lentus and Bacillus alvei also shows antibacterial activity against Staphylococcus aureus. Bacillus pumillus only show slight zone of inhibition on Proteus spp while it is inactive against others.

Siibak T, Peil L, Xiong L et al. (2009) Erythromycin‐ and chloramphenicol‐induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. Antimicrobial Agents and Chemotherapy 53: 563–571.

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  • Antibiotics: Inhibitors of Protein Synthesis

    Bhuyan BK (1967) Pactamycin, an antibiotic that inhibits protein synthesis. Biochemical Pharmacology 16: 1411–1420.

  • Inhibition of protein synthesis by polypeptide antibiotics

    A protein synthesis ..

  • Antibiotic Inhibition of Protein Synthesis

    Inhibition of cell wall synthesis 2

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Inhibition of protein synthesis 4

Brandi L, Lazzarini A, Cavaletti L et al. (2006b) Novel tetrapeptide inhibitors of bacterial protein synthesis produced by a Streptomyces sp. Biochemistry 45: 3692–3702.

Inhibitors of Initiation Phase of Bacterial Protein Synthesis

Hallick RB, Chelm BK, Gray PW and Orozco EM Jr (1977) Use of aurintricarboxylic acid as an inhibitor of nucleases during nucleic acid isolation. Nucleic Acids Research 4: 3055–3064.

are secondary effects of protein synthesis inhibition

GE81112 targets the small subunit to inhibit translation initiation. (a) Chemical structure of the tetrapeptide antibiotic GE81112 isoforms A, B and B1 (Brandi , ). (b) Ribosomal components of the small subunit (grey) involved in GE81112 binding, namely 16S rRNA helices 23 (green) and 24 (magenta). (c) GE81112 protects C693 in h23 from Kethoxal modification and enhances the modification of A795 in h24 by DMS (Brandi , ). (d) Superimposition of kasugamycin (Ksg/Ksg2, orange), edeine (Ede, purple) and pactamycin (Pct, cyan) relative to h23/h24.

Antibiotic inhibition of protein synthesis by …

Jenner L, Romby P, Rees B et al. (2005) Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding. Science 308: 120–123.

Mechanism of protein synthesis inhibition by fusidic …

Kaberdina AC, Szaflarski W, Nierhaus KH and Moll I (2009) An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis? Molecular Cell 33: 227–236.

Inhibition of Protein Synthesis by Chloramphenicol

L. (St. Jude Children's Research Hospital, Memphis, Tenn.). Inhibition of protein synthesis by polypeptide antibiotics. I. Inhibition in intact bacteria. J. Bacteriol. 90:1102–1108. 1965.—The mechanism of inhibition of growth of cells by the polypeptide antibiotics of the PA 114, vernamycin, and streptogramin complexes was studied. This inhibition apparently was due to the selective inhibition of protein synthesis by these antibiotics. Ribonucleic acid synthesis was unaffected by concentrations of the antibiotics which completely inhibited protein synthesis. Deoxyribonucleic acid synthesis was slightly inhibited. These antibiotics are composed of a number of components. Mixtures of equal amounts of PA 114 A and PA 114 B or vernamycin A and Bα were more active in stopping protein synthesis in intact cells than each of the components of the antibiotic complex alone. Mutants resistant to one of the antibiotics were resistant to all of the group and, in addition, were resistant to erythromycin and oleandomycin.

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